Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application

P. Lingor, K. Unsicker, K. Krieglstein

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

29 Zitate (Scopus)

Abstract

Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.

OriginalspracheEnglisch
Seiten (von - bis)139-144
Seitenumfang6
FachzeitschriftJournal of Neural Transmission
Jahrgang106
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - 1999
Extern publiziertJa

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