Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Patrick T. Ellinor; Kathryn L. Lunetta; Christine M. Albert; Nicole L. Glazer; Marylyn D. Ritchie; Albert V. Smith; Dan E. Arking; Martina Müller-Nurasyid; Bouwe P. Krijthe; Steven A. Lubitz; Joshua C. Bis; Mina K. Chung; Marcus Dörr; Kouichi Ozaki; Jason D. Roberts; J. Gustav Smith; Arne Pfeufer; Moritz F. Sinner; Kurt Lohman; Jingzhong Ding; Nicholas L. Smith; Jonathan D. Smith; Michiel Rienstra; Kenneth M. Rice; David R. Van Wagoner; Jared W. Magnani; Reza Wakili; Sebastian Clauss; Jerome I. Rotter; Gerhard Steinbeck; Lenore J. Launer; Robert W. Davies; Matthew Borkovich; Tamara B. Harris; Honghuang Lin; Uwe Völker; Henry Völzke; David J. Milan; Albert Hofman; Eric Boerwinkle; Lin Y. Chen; Elsayed Z. Soliman; Benjamin F. Voight; Guo Li; Aravinda Chakravarti; Michiaki Kubo; Usha B. Tedrow; Lynda M. Rose; Paul M. Ridker; David Conen; Tatsuhiko Tsunoda; Tetsushi Furukawa; Nona Sotoodehnia; Siyan Xu; Naoyuki Kamatani; Daniel Levy; Yusuke Nakamura; Babar Parvez; Saagar Mahida; Karen L. Furie; Jonathan Rosand; Raafia Muhammad; Bruce M. Psaty; Thomas Meitinger; Siegfried Perz; H. Erich Wichmann; Jacqueline C.M. Witteman; W. H.Linda Kao; Sekar Kathiresan; Dan M. Roden; Andre G. Uitterlinden; Fernando Rivadeneira; Barbara McKnight; Marketa Sjögren; Anne B. Newman; Yongmei Liu; Michael H. Gollob; Olle Melander; Toshihiro Tanaka; Bruno H.Ch Stricker; Stephan B. Felix; Alvaro Alonso; Dawood Darbar; John Barnard; Daniel I. Chasman; Susan R. Heckbert; Emelia J. Benjamin; Vilmundur Gudnason; Stefan Kääb

doi:10.1038/ng.2261

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Patrick T. Ellinor, Kathryn L. Lunetta, Christine M. Albert, Nicole L. Glazer, Marylyn D. Ritchie, Albert V. Smith, Dan E. Arking, Martina Müller-Nurasyid, Bouwe P. Krijthe, Steven A. Lubitz, Joshua C. Bis, Mina K. Chung, Marcus Dörr, Kouichi Ozaki, Jason D. Roberts, J. Gustav Smith, Arne Pfeufer, Moritz F. Sinner, Kurt Lohman, Jingzhong DingNicholas L. Smith, Jonathan D. Smith, Michiel Rienstra, Kenneth M. Rice, David R. Van Wagoner, Jared W. Magnani, Reza Wakili, Sebastian Clauss, Jerome I. Rotter, Gerhard Steinbeck, Lenore J. Launer, Robert W. Davies, Matthew Borkovich, Tamara B. Harris, Honghuang Lin, Uwe Völker, Henry Völzke, David J. Milan, Albert Hofman, Eric Boerwinkle, Lin Y. Chen, Elsayed Z. Soliman, Benjamin F. Voight, Guo Li, Aravinda Chakravarti, Michiaki Kubo, Usha B. Tedrow, Lynda M. Rose, Paul M. Ridker, David Conen, Tatsuhiko Tsunoda, Tetsushi Furukawa, Nona Sotoodehnia, Siyan Xu, Naoyuki Kamatani, Daniel Levy, Yusuke Nakamura, Babar Parvez, Saagar Mahida, Karen L. Furie, Jonathan Rosand, Raafia Muhammad, Bruce M. Psaty, Thomas Meitinger, Siegfried Perz, H. Erich Wichmann, Jacqueline C.M. Witteman, W. H.Linda Kao, Sekar Kathiresan, Dan M. Roden, Andre G. Uitterlinden, Fernando Rivadeneira, Barbara McKnight, Marketa Sjögren, Anne B. Newman, Yongmei Liu, Michael H. Gollob, Olle Melander, Toshihiro Tanaka, Bruno H.Ch Stricker, Stephan B. Felix, Alvaro Alonso, Dawood Darbar, John Barnard, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Vilmundur Gudnason, Stefan Kääb

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

488 Zitate (Scopus)

Abstract

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10^-8). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

Originalsprache	Englisch
Seiten (von - bis)	670-675
Seitenumfang	6
Fachzeitschrift	Nature Genetics
Jahrgang	44
Ausgabenummer	6
DOIs	https://doi.org/10.1038/ng.2261
Publikationsstatus	Veröffentlicht - Juni 2012
Extern publiziert	Ja

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10.1038/ng.2261

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Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., Arking, D. E., Müller-Nurasyid, M., Krijthe, B. P., Lubitz, S. A., Bis, J. C., Chung, M. K., Dörr, M., Ozaki, K., Roberts, J. D., Smith, J. G., Pfeufer, A., Sinner, M. F., Lohman, K., ... Kääb, S. (2012). Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44(6), 670-675. https://doi.org/10.1038/ng.2261

@article{562357bec3014ff09b076fdf9c035700,

title = "Meta-analysis identifies six new susceptibility loci for atrial fibrillation",

abstract = "Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10-8). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.",

author = "Ellinor, {Patrick T.} and Lunetta, {Kathryn L.} and Albert, {Christine M.} and Glazer, {Nicole L.} and Ritchie, {Marylyn D.} and Smith, {Albert V.} and Arking, {Dan E.} and Martina M{\"u}ller-Nurasyid and Krijthe, {Bouwe P.} and Lubitz, {Steven A.} and Bis, {Joshua C.} and Chung, {Mina K.} and Marcus D{\"o}rr and Kouichi Ozaki and Roberts, {Jason D.} and Smith, {J. Gustav} and Arne Pfeufer and Sinner, {Moritz F.} and Kurt Lohman and Jingzhong Ding and Smith, {Nicholas L.} and Smith, {Jonathan D.} and Michiel Rienstra and Rice, {Kenneth M.} and {Van Wagoner}, {David R.} and Magnani, {Jared W.} and Reza Wakili and Sebastian Clauss and Rotter, {Jerome I.} and Gerhard Steinbeck and Launer, {Lenore J.} and Davies, {Robert W.} and Matthew Borkovich and Harris, {Tamara B.} and Honghuang Lin and Uwe V{\"o}lker and Henry V{\"o}lzke and Milan, {David J.} and Albert Hofman and Eric Boerwinkle and Chen, {Lin Y.} and Soliman, {Elsayed Z.} and Voight, {Benjamin F.} and Guo Li and Aravinda Chakravarti and Michiaki Kubo and Tedrow, {Usha B.} and Rose, {Lynda M.} and Ridker, {Paul M.} and David Conen and Tatsuhiko Tsunoda and Tetsushi Furukawa and Nona Sotoodehnia and Siyan Xu and Naoyuki Kamatani and Daniel Levy and Yusuke Nakamura and Babar Parvez and Saagar Mahida and Furie, {Karen L.} and Jonathan Rosand and Raafia Muhammad and Psaty, {Bruce M.} and Thomas Meitinger and Siegfried Perz and Wichmann, {H. Erich} and Witteman, {Jacqueline C.M.} and Kao, {W. H.Linda} and Sekar Kathiresan and Roden, {Dan M.} and Uitterlinden, {Andre G.} and Fernando Rivadeneira and Barbara McKnight and Marketa Sj{\"o}gren and Newman, {Anne B.} and Yongmei Liu and Gollob, {Michael H.} and Olle Melander and Toshihiro Tanaka and Stricker, {Bruno H.Ch} and Felix, {Stephan B.} and Alvaro Alonso and Dawood Darbar and John Barnard and Chasman, {Daniel I.} and Heckbert, {Susan R.} and Benjamin, {Emelia J.} and Vilmundur Gudnason and Stefan K{\"a}{\"a}b",

year = "2012",

month = jun,

doi = "10.1038/ng.2261",

language = "English",

volume = "44",

pages = "670--675",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "6",

}

Ellinor, PT, Lunetta, KL, Albert, CM, Glazer, NL, Ritchie, MD, Smith, AV, Arking, DE, Müller-Nurasyid, M, Krijthe, BP, Lubitz, SA, Bis, JC, Chung, MK, Dörr, M, Ozaki, K, Roberts, JD, Smith, JG, Pfeufer, A, Sinner, MF, Lohman, K, Ding, J, Smith, NL, Smith, JD, Rienstra, M, Rice, KM, Van Wagoner, DR, Magnani, JW, Wakili, R, Clauss, S, Rotter, JI, Steinbeck, G, Launer, LJ, Davies, RW, Borkovich, M, Harris, TB, Lin, H, Völker, U, Völzke, H, Milan, DJ, Hofman, A, Boerwinkle, E, Chen, LY, Soliman, EZ, Voight, BF, Li, G, Chakravarti, A, Kubo, M, Tedrow, UB, Rose, LM, Ridker, PM, Conen, D, Tsunoda, T, Furukawa, T, Sotoodehnia, N, Xu, S, Kamatani, N, Levy, D, Nakamura, Y, Parvez, B, Mahida, S, Furie, KL, Rosand, J, Muhammad, R, Psaty, BM, Meitinger, T, Perz, S, Wichmann, HE, Witteman, JCM, Kao, WHL, Kathiresan, S, Roden, DM, Uitterlinden, AG, Rivadeneira, F, McKnight, B, Sjögren, M, Newman, AB, Liu, Y, Gollob, MH, Melander, O, Tanaka, T, Stricker, BHC, Felix, SB, Alonso, A, Darbar, D, Barnard, J, Chasman, DI, Heckbert, SR, Benjamin, EJ, Gudnason, V & Kääb, S 2012, 'Meta-analysis identifies six new susceptibility loci for atrial fibrillation', Nature Genetics, Jg. 44, Nr. 6, S. 670-675. https://doi.org/10.1038/ng.2261

TY - JOUR

T1 - Meta-analysis identifies six new susceptibility loci for atrial fibrillation

AU - Ellinor, Patrick T.

AU - Lunetta, Kathryn L.

AU - Albert, Christine M.

AU - Glazer, Nicole L.

AU - Ritchie, Marylyn D.

AU - Smith, Albert V.

AU - Arking, Dan E.

AU - Müller-Nurasyid, Martina

AU - Krijthe, Bouwe P.

AU - Lubitz, Steven A.

AU - Bis, Joshua C.

AU - Chung, Mina K.

AU - Dörr, Marcus

AU - Ozaki, Kouichi

AU - Roberts, Jason D.

AU - Smith, J. Gustav

AU - Pfeufer, Arne

AU - Sinner, Moritz F.

AU - Lohman, Kurt

AU - Ding, Jingzhong

AU - Smith, Nicholas L.

AU - Smith, Jonathan D.

AU - Rienstra, Michiel

AU - Rice, Kenneth M.

AU - Van Wagoner, David R.

AU - Magnani, Jared W.

AU - Wakili, Reza

AU - Clauss, Sebastian

AU - Rotter, Jerome I.

AU - Steinbeck, Gerhard

AU - Launer, Lenore J.

AU - Davies, Robert W.

AU - Borkovich, Matthew

AU - Harris, Tamara B.

AU - Lin, Honghuang

AU - Völker, Uwe

AU - Völzke, Henry

AU - Milan, David J.

AU - Hofman, Albert

AU - Boerwinkle, Eric

AU - Chen, Lin Y.

AU - Soliman, Elsayed Z.

AU - Voight, Benjamin F.

AU - Li, Guo

AU - Chakravarti, Aravinda

AU - Kubo, Michiaki

AU - Tedrow, Usha B.

AU - Rose, Lynda M.

AU - Ridker, Paul M.

AU - Conen, David

AU - Tsunoda, Tatsuhiko

AU - Furukawa, Tetsushi

AU - Sotoodehnia, Nona

AU - Xu, Siyan

AU - Kamatani, Naoyuki

AU - Levy, Daniel

AU - Nakamura, Yusuke

AU - Parvez, Babar

AU - Mahida, Saagar

AU - Furie, Karen L.

AU - Rosand, Jonathan

AU - Muhammad, Raafia

AU - Psaty, Bruce M.

AU - Meitinger, Thomas

AU - Perz, Siegfried

AU - Wichmann, H. Erich

AU - Witteman, Jacqueline C.M.

AU - Kao, W. H.Linda

AU - Kathiresan, Sekar

AU - Roden, Dan M.

AU - Uitterlinden, Andre G.

AU - Rivadeneira, Fernando

AU - McKnight, Barbara

AU - Sjögren, Marketa

AU - Newman, Anne B.

AU - Liu, Yongmei

AU - Gollob, Michael H.

AU - Melander, Olle

AU - Tanaka, Toshihiro

AU - Stricker, Bruno H.Ch

AU - Felix, Stephan B.

AU - Alonso, Alvaro

AU - Darbar, Dawood

AU - Barnard, John

AU - Chasman, Daniel I.

AU - Heckbert, Susan R.

AU - Benjamin, Emelia J.

AU - Gudnason, Vilmundur

AU - Kääb, Stefan

PY - 2012/6

Y1 - 2012/6

N2 - Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10-8). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

AB - Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10-8). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

UR - http://www.scopus.com/inward/record.url?scp=84861636519&partnerID=8YFLogxK

U2 - 10.1038/ng.2261

DO - 10.1038/ng.2261

M3 - Article

C2 - 22544366

AN - SCOPUS:84861636519

SN - 1061-4036

VL - 44

SP - 670

EP - 675

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Abstract

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