TY - JOUR
T1 - Lipocalins in drug discovery
T2 - From natural ligand-binding proteins to 'anticalins'
AU - Schlehuber, Steffen
AU - Skerra, Arne
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Lipocalins are a widespread family of small, robust proteins that typically transport or store biological compounds which are either oflow solubility or are chemically sensitive, including vitamins, steroid hormones, odorants and various secondary metabolites. There are approximately ten different lipocalins in the human body, with the plasma retinol-binding protein being the most well known. Some lipocalins have a pathophysiological role, which opens possibilities for their use in medical applications. Furthermore, lipocalins from blood-sucking insects have evolved as scavengers for mediators of inflammation. As well as using the natural ligand-binding function, lipocalins have also been recruited as scaffolds for the design of artificial binding proteins termed 'anticalins'®. These novel proteins have potential applications as antidotes, antagonistic protein therapeutics or as target-recognition modules in a new generation of immunotoxins.
AB - Lipocalins are a widespread family of small, robust proteins that typically transport or store biological compounds which are either oflow solubility or are chemically sensitive, including vitamins, steroid hormones, odorants and various secondary metabolites. There are approximately ten different lipocalins in the human body, with the plasma retinol-binding protein being the most well known. Some lipocalins have a pathophysiological role, which opens possibilities for their use in medical applications. Furthermore, lipocalins from blood-sucking insects have evolved as scavengers for mediators of inflammation. As well as using the natural ligand-binding function, lipocalins have also been recruited as scaffolds for the design of artificial binding proteins termed 'anticalins'®. These novel proteins have potential applications as antidotes, antagonistic protein therapeutics or as target-recognition modules in a new generation of immunotoxins.
KW - Bilin-binding protein
KW - Biochemistry
KW - Calycin
KW - Chemical Biology
KW - Drug Discovery
KW - Hapten
KW - Pharmaceutical Science
KW - Plasma protein
KW - Protein engineering
KW - Retinol-binding protein
UR - http://www.scopus.com/inward/record.url?scp=12844276589&partnerID=8YFLogxK
U2 - 10.1016/S1359-6446(04)03294-5
DO - 10.1016/S1359-6446(04)03294-5
M3 - Review article
C2 - 15676296
AN - SCOPUS:12844276589
SN - 1359-6446
VL - 10
SP - 23
EP - 33
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -