L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR

Bastian Blombach, Annette Arndt, Marc Auchter, Bernhard J. Eikmanns

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

50 Zitate (Scopus)

Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L- valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

OriginalspracheEnglisch
Seiten (von - bis)1197-1200
Seitenumfang4
FachzeitschriftApplied and Environmental Microbiology
Jahrgang75
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - Feb. 2009
Extern publiziertJa

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