TY - JOUR
T1 - Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting
T2 - First in-human results
AU - Van Dam, Gooitzen M.
AU - Themelis, George
AU - Crane, Lucia M.A.
AU - Harlaar, Niels J.
AU - Pleijhuis, Rick G.
AU - Kelder, Wendy
AU - Sarantopoulos, Athanasios
AU - De Jong, Johannes S.
AU - Arts, Henriette J.G.
AU - Van Der Zee, Ate G.J.
AU - Bart, Joost
AU - Low, Philip S.
AU - Ntziachristos, Vasilis
PY - 2011/10
Y1 - 2011/10
N2 - The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
AB - The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
UR - http://www.scopus.com/inward/record.url?scp=80053989452&partnerID=8YFLogxK
U2 - 10.1038/nm.2472
DO - 10.1038/nm.2472
M3 - Article
C2 - 21926976
AN - SCOPUS:80053989452
SN - 1078-8956
VL - 17
SP - 1315
EP - 1319
JO - Nature Medicine
JF - Nature Medicine
IS - 10
ER -
