Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors

Keyphrases

• Hepatitis B Virus 100%
• Virus Genome 100%
• Circulating Tumor DNA (ctDNA) 100%
• Recombinant AAV 100%
• Genome Transfer 100%
• Intramolecular Recombination 100%
• AAV Vector 100%
• Recombinant Adeno-associated Virus Vector 42%
• Mouse Liver 21%
• Hepatitis B Virus Infection 14%
• Viral Transcription 14%
• Core Protein 14%
• Overlength 14%
• Protein Expression 7%
• Genotype 7%
• Upstream Open Reading Frame (uORF) 7%
• Mouse Model 7%
• Sequence Analysis 7%
• Three-core 7%
• Human Liver Cells 7%
• Hepatitis B Virus Replication 7%
• Hepatocytes 7%
• Covalently Closed Circular DNA 7%
• Hepatitis B Virus Receptor 7%
• Hepatitis B Virus Genotype 7%
• Viral Proteins 7%
• Transcription Expression 7%
• Genotype A 7%
• Genotype D 7%
• Hepatitis B e Antigen (HBeAg) 7%
• Persistent Infection 7%
• Genotype B 7%
• Amplicon 7%
• Exonuclease Digestion 7%
• Premature Stop Codon 7%
• Stop Codon 7%
• Engraftment 7%
• Mouse Hepatocytes 7%
• Genome Delivery 7%
• Constant Losses 7%
• Natural Host 7%
• Restriction Digestion 7%
• Type Sequences 7%

Immunology and Microbiology

• Restriction Enzyme 7%