Abstract
The cellular cortex is a dynamic and contractile actomyosin network modulated by actin-binding proteins. We reconstituted a minimal cortex adhered to a model cell membrane mimicking two processes mediated by the motor protein myosin: contractility and high turnover of actin monomers. Myosin reorganized these networks by extensile intra‑bundle contractions leading to an altered growth mechanism. Hereby, stress within tethered bundles induced nicking of filaments followed by repair via incorporation of free monomers. This mechanism was able to break the symmetry of the previously disordered network resulting in the generation of extensile clusters, reminiscent of structures found within cells.
Originalsprache | Englisch |
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Aufsatznummer | 2677 |
Fachzeitschrift | Scientific Reports |
Jahrgang | 11 |
Ausgabenummer | 1 |
DOIs | |
Publikationsstatus | Veröffentlicht - Dez. 2021 |