Internalization of glimepiride and glibenclamide in the pancreatic B-cell

G. Marynissen; G. Smets; G. Klöppel; L. Gerlache; W. J. Malaisse

doi:10.1007/BF00572555

Internalization of glimepiride and glibenclamide in the pancreatic B-cell

G. Marynissen, G. Smets, G. Klöppel, L. Gerlache, W. J. Malaisse

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

15 Zitate (Scopus)

Abstract

When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

Originalsprache	Englisch
Seiten (von - bis)	113-114
Seitenumfang	2
Fachzeitschrift	Acta Diabetologica
Jahrgang	29
Ausgabenummer	2
DOIs	https://doi.org/10.1007/BF00572555
Publikationsstatus	Veröffentlicht - Juni 1992
Extern publiziert	Ja

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title = "Internalization of glimepiride and glibenclamide in the pancreatic B-cell",

abstract = "When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.",

keywords = "Glibenclamide, Glimepiride, Pancreatic islets",

author = "G. Marynissen and G. Smets and G. Kl{\"o}ppel and L. Gerlache and Malaisse, {W. J.}",

year = "1992",

month = jun,

doi = "10.1007/BF00572555",

language = "English",

volume = "29",

pages = "113--114",

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AU - Marynissen, G.

AU - Smets, G.

AU - Klöppel, G.

AU - Gerlache, L.

AU - Malaisse, W. J.

PY - 1992/6

Y1 - 1992/6

N2 - When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

AB - When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

KW - Glibenclamide

KW - Glimepiride

KW - Pancreatic islets

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JO - Acta Diabetologica

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ER -

Internalization of glimepiride and glibenclamide in the pancreatic B-cell

Abstract

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