Interleukin-6 in inflammatory and malignant diseases of the pancreas

Marina Lesina; Sonja Maria Wörmann; Patrick Neuhöfer; Liang Song; Hana Algül

doi:10.1016/j.smim.2014.01.002

Interleukin-6 in inflammatory and malignant diseases of the pancreas

Marina Lesina, Sonja Maria Wörmann, Patrick Neuhöfer, Liang Song, Hana Algül

Technische Universität München

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

113 Zitate (Scopus)

Abstract

Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.

Originalsprache	Englisch
Seiten (von - bis)	80-87
Seitenumfang	8
Fachzeitschrift	Seminars in Immunology
Jahrgang	26
Ausgabenummer	1
DOIs	https://doi.org/10.1016/j.smim.2014.01.002
Publikationsstatus	Veröffentlicht - Feb. 2014
Extern publiziert	Ja

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1016/j.smim.2014.01.002

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

Dieses zitieren

@article{67d3f57c4e0a46ec99eedab4a12cc3eb,

title = "Interleukin-6 in inflammatory and malignant diseases of the pancreas",

abstract = "Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.",

keywords = "Acute pancreatitis, Chronic pancreatitis, IL-6 signaling, IL-6 trans-signaling, Pancreatic cancer, STAT3",

author = "Marina Lesina and W{\"o}rmann, {Sonja Maria} and Patrick Neuh{\"o}fer and Liang Song and Hana Alg{\"u}l",

note = "Funding Information: This work was supported by grants from the Deutsche Forschungsgemeinschaft ( AL 1174/3-1 ; AL 1174/4-1 ) and by Deutsche Krebshilfe ( 109445 ).",

year = "2014",

month = feb,

doi = "10.1016/j.smim.2014.01.002",

language = "English",

volume = "26",

pages = "80--87",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Interleukin-6 in inflammatory and malignant diseases of the pancreas

AU - Lesina, Marina

AU - Wörmann, Sonja Maria

AU - Neuhöfer, Patrick

AU - Song, Liang

AU - Algül, Hana

N1 - Funding Information: This work was supported by grants from the Deutsche Forschungsgemeinschaft ( AL 1174/3-1 ; AL 1174/4-1 ) and by Deutsche Krebshilfe ( 109445 ).

PY - 2014/2

Y1 - 2014/2

N2 - Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.

AB - Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.

KW - Acute pancreatitis

KW - Chronic pancreatitis

KW - IL-6 signaling

KW - IL-6 trans-signaling

KW - Pancreatic cancer

KW - STAT3

UR - http://www.scopus.com/inward/record.url?scp=84896493991&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2014.01.002

DO - 10.1016/j.smim.2014.01.002

M3 - Review article

C2 - 24572992

AN - SCOPUS:84896493991

SN - 1044-5323

VL - 26

SP - 80

EP - 87

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 1

ER -

Interleukin-6 in inflammatory and malignant diseases of the pancreas

Abstract

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren