Interleukin-17 and type 17 helper T cells

Pierre Miossec; Thomas Korn; Vijay K. Kuchroo

doi:10.1056/NEJMra0707449

Interleukin-17 and type 17 helper T cells

Pierre Miossec, Thomas Korn, Vijay K. Kuchroo

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Abstract

Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.

Originalsprache	Englisch
Seiten (von - bis)	888
Seitenumfang	1
Fachzeitschrift	New England Journal of Medicine
Jahrgang	361
Ausgabenummer	9
DOIs	https://doi.org/10.1056/NEJMra0707449
Publikationsstatus	Veröffentlicht - 27 Aug. 2009

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title = "Interleukin-17 and type 17 helper T cells",

abstract = "Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.",

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AB - Type 17 helper T cells (Th17) - a third class of T cells - and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.

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Interleukin-17 and type 17 helper T cells

Abstract

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