@article{cd2ea8ac606544fba9d2cb83bf626232,
title = "Insights into the in Vitro and in Vivo SAR of Abscisic Acid – Exploring Unprecedented Variations of the Side Chain via Cross-Coupling-Mediated Syntheses",
abstract = "Novel analogues of the plant hormone abscisic acid (ABA) were designed and prepared to explore the impact that modifications of its terpenoid side chain have on receptor affinity and in vivo efficacy against drought stress in selected crops. Their efficient and versatile synthesis proceeded via Stille or Sonogashira couplings, shortening the synthetic route significantly. In line with molecular modelling and X-ray crystallography studies novel ABA-derivatives with small alkyl, cycloalkyl or haloalkyl substituents showed strong effects in vitro and in vivo against drought stress in crops, particularly canola and wheat.",
keywords = "Drought stress, Phytochemistry, Plant hormone, Stille coupling, Terpenoids",
author = "Jens Frackenpohl and Erwin Grill and Guido Bojack and Rachel Baltz and Marco Busch and Jan Dittgen and Jana Franke and J{\"o}rg Freigang and Susana Gonzalez and Ines Heinemann and Hendrik Helmke and Martin Hills and Sabine Hohmann and {von Koskull-D{\"o}ring}, Pascal and Jochen Kleemann and Gudrun Lange and Stefan Lehr and Thomas M{\"u}ller and Elisabeth Peschel and Fabien Poree and Dirk Schmutzler and Arno Schulz and Lothar Willms and Christian Wunschel",
note = "Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = mar,
day = "29",
doi = "10.1002/ejoc.201701687",
language = "English",
volume = "2018",
pages = "1403--1415",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley-VCH Verlag",
number = "12",
}