In vitro perfusion technique for investigations on the intestinal transport of water soluble substances

Gertrud Rehner, Hannelore Daniel, Renate Aeppli-Schmidt

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

1 Zitat (Scopus)

Abstract

A new method for the in vitro perfusion of isolated intestinal segments of laboratory animals is described. Everted intestinal segments are used in an "open perfusion system," and are incubated in a buffer solution containing the substrate to be absorbed as a radiolabeled compound. The solutes absorbed are removed from the serosal side in a buffer solution that is collected by a fraction collector. The technique permits studies on the mechanism and the kinetics of the intestinal transport of water soluble substances.

OriginalspracheEnglisch
Seiten (von - bis)193-201
Seitenumfang9
FachzeitschriftJournal of Pharmacological Methods
Jahrgang5
Ausgabenummer3
DOIs
PublikationsstatusVeröffentlicht - Mai 1981
Extern publiziertJa

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