Impact of local versus global ligand density on cellular adhesion

Janosch A. Deeg; Ilia Louban; Daniel Aydin; Christine Selhuber-Unkel; Horst Kessler; Joachim P. Spatz

doi:10.1021/nl104079r

Impact of local versus global ligand density on cellular adhesion

Janosch A. Deeg, Ilia Louban, Daniel Aydin, Christine Selhuber-Unkel, Horst Kessler, Joachim P. Spatz

TUM Emeriti of Excellence

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

141 Zitate (Scopus)

Abstract

α_vβ₃ integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

Originalsprache	Englisch
Seiten (von - bis)	1469-1476
Seitenumfang	8
Fachzeitschrift	Nano Letters
Jahrgang	11
Ausgabenummer	4
DOIs	https://doi.org/10.1021/nl104079r
Publikationsstatus	Veröffentlicht - 13 Apr. 2011

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10.1021/nl104079r

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AU - Deeg, Janosch A.

AU - Louban, Ilia

AU - Aydin, Daniel

AU - Selhuber-Unkel, Christine

AU - Kessler, Horst

AU - Spatz, Joachim P.

PY - 2011/4/13

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N2 - αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

AB - αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

KW - ECM

KW - Integrin

KW - biointerfaces

KW - focal adhesion

KW - micronanostructures

KW - single cell force spectroscopy (SCFS)

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SP - 1469

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JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Impact of local versus global ligand density on cellular adhesion

Abstract

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