Abstract
Currently two calcineurin inhibitors (cyclosporin A, tacrolimus), three DNA synthesis inhibitors (mycophenolate, mycophenolatmofetil, azathioprin) and two TOR inhibitors (everolimus, sirolimus) are used for immunosuppressant therapy in kidney transplant recipients. Steroids and different types of antibodies may extend immunosuppressant regimens. The present article discusses pharmacokinetic data, adverse effects and interaction profiles of these drugs and the possibilities opened up by various combinations in current use and their limitations; it also deals with current guidelines on treating rejection.
| Titel in Übersetzung | Immunosuppressants in the treatment of kidney transplant recipients |
|---|---|
| Originalsprache | Deutsch |
| Seiten (von - bis) | 157-166 |
| Seitenumfang | 10 |
| Fachzeitschrift | Nephrologe |
| Jahrgang | 2 |
| Ausgabenummer | 3 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - Mai 2007 |
| Extern publiziert | Ja |
Schlagwörter
- Calcineurin inhibitors
- DNA synthesis inhibitors
- Immunosuppressant treatment
- Kidney transplantation
- TOR inhibitors