TY - JOUR
T1 - IL-23 past, present, and future
T2 - a roadmap to advancing IL-23 science and therapy
AU - Krueger, James G.
AU - Eyerich, Kilian
AU - Kuchroo, Vijay K.
AU - Ritchlin, Christopher T.
AU - Abreu, Maria T.
AU - Elloso, M. Merle
AU - Fourie, Anne
AU - Fakharzadeh, Steven
AU - Sherlock, Jonathan P.
AU - Yang, Ya Wen
AU - Cua, Daniel J.
AU - McInnes, Iain B.
N1 - Publisher Copyright:
Copyright © 2024 Krueger, Eyerich, Kuchroo, Ritchlin, Abreu, Elloso, Fourie, Fakharzadeh, Sherlock, Yang, Cua and McInnes.
PY - 2024
Y1 - 2024
N2 - Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23–driven diseases, improve upon current approaches to treating IMIDs with IL-23 inhibition, and ultimately facilitate optimal identification of patients and, thereby, outcomes.
AB - Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23–driven diseases, improve upon current approaches to treating IMIDs with IL-23 inhibition, and ultimately facilitate optimal identification of patients and, thereby, outcomes.
KW - IL-23
KW - cytokine
KW - immune-mediated inflammatory diseases
KW - inflammatory bowel disease
KW - psoriasis
KW - psoriatic arthritis
UR - https://www.scopus.com/pages/publications/85191927495
U2 - 10.3389/fimmu.2024.1331217
DO - 10.3389/fimmu.2024.1331217
M3 - Review article
C2 - 38686385
AN - SCOPUS:85191927495
SN - 1664-3224
VL - 15
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1331217
ER -