TY - JOUR
T1 - IL-17 and IL-22
T2 - siblings, not twins
AU - Eyerich, Stefanie
AU - Eyerich, Kilian
AU - Cavani, Andrea
AU - Schmidt-Weber, Carsten
PY - 2010/9
Y1 - 2010/9
N2 - T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.
AB - T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.
UR - http://www.scopus.com/inward/record.url?scp=77956181347&partnerID=8YFLogxK
U2 - 10.1016/j.it.2010.06.004
DO - 10.1016/j.it.2010.06.004
M3 - Review article
C2 - 20691634
AN - SCOPUS:77956181347
SN - 1471-4906
VL - 31
SP - 354
EP - 361
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -