Human T-lymphotropic virus type I-associated myelopathy in patients with the acquired immunodeficiency syndrome

Marc K. Rosenblum, Bruce J. Brew, Beatrice Hahn, George Shaw, Ashley Haase, Stacene Maroushek, Richard W. Price

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

11 Zitate (Scopus)

Abstract

We describe two cases of serologically confirmed human T-lymphotropic virus type I (HTLV-I)-associated myelopathy involving North American men coinfected by the human immunodeficiency virus type 1. Our first patient suffered from a gradually progressive spastic paraparesis for 10 years prior to presenting with Kaposi's sarcoma, while our second patient developed subacutely progressive spastic paraparesis in the setting of full-blown acquired immunodeficiency syndrome. Autopsy examination of the spinal cords from these two cases revealed widespread axonal loss and demyelination principally involving the lateral columns of case no. 1 and the lateral and anterior columns of case no. 2. Vascular sclerosis and hyalinization were prominent in both cases, but in neither was there a conspicuous inflammatory component. In case no. 2, HTLV-I mRNA was not detected by in situ hybridization, but HTLV-I proviral DNA sequences were detected in this case by polymerase chain reaction. Neither case exhibited multinucleated cell (human immunodeficiency virus type 1) myelitis, vacuolar myelopathy, or evidence of HTLV-II infection by polymerase chain reaction assay.

OriginalspracheEnglisch
Seiten (von - bis)513-519
Seitenumfang7
FachzeitschriftHuman Pathology
Jahrgang23
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - Mai 1992
Extern publiziertJa

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