Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation

Biebl et al. show that Hsp90 co-chaperones form client-specific genetic networks for client maturation. Tightly interacting core genetic modules of co-chaperones specific for a client are embedded in a network of looser genetic interactions. Distinct epistatic Hsp90 co-chaperone modules regulate kinase activation, steroid hormone receptor maturation, and protein biosynthesis.