TY - JOUR
T1 - HIAPP forms toxic oligomers in plasma
AU - Rodriguez Camargo, Diana C.
AU - Garg, Divita
AU - Buday, Katalin
AU - Franko, Andras
AU - Rodriguez Camargo, Andres
AU - Schmidt, Fabian
AU - Cox, Sarah J.
AU - Suladze, Saba
AU - Haslbeck, Martin
AU - Mideksa, Yonatan G.
AU - Gemmecker, Gerd
AU - Aichler, Michaela
AU - Mettenleiter, Gabriele
AU - Schulz, Michael
AU - Walch, Axel Karl
AU - Hrabě De Angelis, Martin
AU - Feige, Matthias J.
AU - Sierra, Cesar A.
AU - Conrad, Marcus
AU - Tripsianes, Konstantinos
AU - Ramamoorthy, Ayyalusamy
AU - Reif, Bernd
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2018.
PY - 2018
Y1 - 2018
N2 - In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
AB - In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
UR - http://www.scopus.com/inward/record.url?scp=85047566079&partnerID=8YFLogxK
U2 - 10.1039/c8cc03097a
DO - 10.1039/c8cc03097a
M3 - Article
C2 - 29745410
AN - SCOPUS:85047566079
SN - 1359-7345
VL - 54
SP - 5426
EP - 5429
JO - Chemical Communications
JF - Chemical Communications
IS - 43
ER -