Head-to-tail cyclization and use of Cα-allyl ester protection improves the yield of cyclic peptides synthesized by the oxime resin method

Afrodite Kapurniotu; John W. Taylor

doi:10.1016/S0040-4039(00)61589-7

Head-to-tail cyclization and use of C^α-allyl ester protection improves the yield of cyclic peptides synthesized by the oxime resin method

Afrodite Kapurniotu, John W. Taylor

Rutgers University–New Brunswick

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

19 Zitate (Scopus)

Abstract

Fully protected and C-terminal free cyclic (lactam-bridged) peptides are assembled by the oxime resin method in high yields and purity applying a four dimensional orthogonal (Boc/Bzl/Fmoc/Al) protection scheme and a head-to-tail cyclization strategy.

Originalsprache	Englisch
Seiten (von - bis)	7031-7034
Seitenumfang	4
Fachzeitschrift	Tetrahedron Letters
Jahrgang	34
Ausgabenummer	44
DOIs	https://doi.org/10.1016/S0040-4039(00)61589-7
Publikationsstatus	Veröffentlicht - 29 Okt. 1993
Extern publiziert	Ja

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10.1016/S0040-4039(00)61589-7

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abstract = "Fully protected and C-terminal free cyclic (lactam-bridged) peptides are assembled by the oxime resin method in high yields and purity applying a four dimensional orthogonal (Boc/Bzl/Fmoc/Al) protection scheme and a head-to-tail cyclization strategy.",

keywords = "allyl ester protection, cyclic peptides, head-to-tail cyclization, human calcitonin, oxime resin, phenacyl ester protection, solid-phase synthesis",

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KW - head-to-tail cyclization

KW - human calcitonin

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KW - phenacyl ester protection

KW - solid-phase synthesis

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