Glycosylation of Candida albicans Cell Wall Proteins Is Critical for Induction of Innate Immune Responses and Apoptosis of Epithelial Cells

Jeanette Wagener, Günther Weindl, Piet W.J. de Groot, Albert D. de Boer, Susanne Kaesler, Selvam Thavaraj, Oliver Bader, Daniela Mailänder-Sanchez, Claudia Borelli, Michael Weig, Tilo Biedermann, Julian R. Naglik, Hans Christian Korting, Martin Schaller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

27 Zitate (Scopus)

Abstract

C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C. albicans interactions is the fungal cell wall, we aimed to identify features of the cell wall inducing epithelial responses and be associated with fungal pathogenesis. We demonstrate here the importance of cell wall protein glycosylation in epithelial immune activation with a predominant role for the highly branched N-glycosylation residues. Moreover, these glycan moieties induce growth arrest and apoptosis of epithelial cells. Using an in vitro model of oral candidosis we demonstrate, that apoptosis induction by C. albicans wild-type occurs in early stage of infection and strongly depends on intact cell wall protein glycosylation. These novel findings demonstrate that glycosylation of the C. albicans cell wall proteins appears essential for modulation of epithelial immunity and apoptosis induction, both of which may promote fungal pathogenesis in vivo.

OriginalspracheEnglisch
Aufsatznummere50518
FachzeitschriftPLoS ONE
Jahrgang7
Ausgabenummer11
DOIs
PublikationsstatusVeröffentlicht - 30 Nov. 2012
Extern publiziertJa

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