Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel, James I. Mullins, Gerald H. Learn, Laura Manns-Arcuino, Belinda L. Herring, Marcia L. Kalish, Richard W. Steketee, Donald M. Thea, Joan E. Nichols, Shan Lu Liu, Abdallah Harmache, Xi He, David Muthui, Anup Madan, Leroy Hood, Ashley T. Haase, Mary Zupancic, Katherine Staskus, Steven Wolinsky, Paul KrogstadJia Qi Zhao, Irvin Chen, Richard Koup, David Ho, Bette Korber, Raymond J. Apple, Robert W. Coombs, Savita Pahwa, Norbert J. Roberts

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

56 Zitate (Scopus)

Abstract

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

OriginalspracheEnglisch
Seiten (von - bis)1073-1077
Seitenumfang5
FachzeitschriftScience
Jahrgang280
Ausgabenummer5366
DOIs
PublikationsstatusVeröffentlicht - 15 Mai 1998
Extern publiziertJa

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