Functional classification of memory CD8 + T cells by CX 3 CR1 expression

Jan P. Böttcher; Marc Beyer; Felix Meissner; Zeinab Abdullah; Jil Sander; Bastian Höchst; Sarah Eickhoff; Jan C. Rieckmann; Caroline Russo; Tanja Bauer; Tobias Flecken; Dominik Giesen; Daniel Engel; Steffen Jung; Dirk H. Busch; Ulrike Protzer; Robert Thimme; Matthias Mann; Christian Kurts; Joachim L. Schultze; Wolfgang Kastenmüller; Percy A. Knolle

doi:10.1038/ncomms9306

Functional classification of memory CD8 + T cells by CX 3 CR1 expression

Jan P. Böttcher, Marc Beyer, Felix Meissner, Zeinab Abdullah, Jil Sander, Bastian Höchst, Sarah Eickhoff, Jan C. Rieckmann, Caroline Russo, Tanja Bauer, Tobias Flecken, Dominik Giesen, Daniel Engel, Steffen Jung, Dirk H. Busch, Ulrike Protzer, Robert Thimme, Matthias Mann, Christian Kurts, Joachim L. SchultzeWolfgang Kastenmüller, Percy A. Knolle

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201 Zitate (Scopus)

Abstract

Localization of memory CD8⁺ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX 3 CR1 distinguishes memory CD8⁺ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX₃ CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8⁺ T cells with effector function. We find CD62L hi CX³ CR1⁺ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX₃CR1⁺ memory CD8⁺ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX₃ CR1-based functional classification will help to resolve the principles of protective CD8⁺ T-cell memory.

Originalsprache	Englisch
Aufsatznummer	8306
Fachzeitschrift	Nature Communications
Jahrgang	6
DOIs	https://doi.org/10.1038/ncomms9306
Publikationsstatus	Veröffentlicht - 25 Sept. 2015

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Böttcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., Flecken, T., Giesen, D., Engel, D., Jung, S., Busch, D. H., Protzer, U., Thimme, R., Mann, M., Kurts, C., ... Knolle, P. A. (2015). Functional classification of memory CD8 + T cells by CX 3 CR1 expression. Nature Communications, 6, Artikel 8306. https://doi.org/10.1038/ncomms9306

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title = "Functional classification of memory CD8 + T cells by CX 3 CR1 expression",

abstract = "Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX 3 CR1 distinguishes memory CD8+ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3 CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8+ T cells with effector function. We find CD62L hi CX3 CR1+ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1+ memory CD8+ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3 CR1-based functional classification will help to resolve the principles of protective CD8+ T-cell memory.",

author = "B{\"o}ttcher, {Jan P.} and Marc Beyer and Felix Meissner and Zeinab Abdullah and Jil Sander and Bastian H{\"o}chst and Sarah Eickhoff and Rieckmann, {Jan C.} and Caroline Russo and Tanja Bauer and Tobias Flecken and Dominik Giesen and Daniel Engel and Steffen Jung and Busch, {Dirk H.} and Ulrike Protzer and Robert Thimme and Matthias Mann and Christian Kurts and Schultze, {Joachim L.} and Wolfgang Kastenm{\"u}ller and Knolle, {Percy A.}",

year = "2015",

month = sep,

day = "25",

doi = "10.1038/ncomms9306",

language = "English",

volume = "6",

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Böttcher, JP, Beyer, M, Meissner, F, Abdullah, Z, Sander, J, Höchst, B, Eickhoff, S, Rieckmann, JC, Russo, C, Bauer, T, Flecken, T, Giesen, D, Engel, D, Jung, S, Busch, DH , Protzer, U, Thimme, R, Mann, M, Kurts, C, Schultze, JL, Kastenmüller, W & Knolle, PA 2015, 'Functional classification of memory CD8 + T cells by CX 3 CR1 expression', Nature Communications, Jg. 6, 8306. https://doi.org/10.1038/ncomms9306

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AU - Böttcher, Jan P.

AU - Beyer, Marc

AU - Meissner, Felix

AU - Abdullah, Zeinab

AU - Sander, Jil

AU - Höchst, Bastian

AU - Eickhoff, Sarah

AU - Rieckmann, Jan C.

AU - Russo, Caroline

AU - Bauer, Tanja

AU - Flecken, Tobias

AU - Giesen, Dominik

AU - Engel, Daniel

AU - Jung, Steffen

AU - Busch, Dirk H.

AU - Protzer, Ulrike

AU - Thimme, Robert

AU - Mann, Matthias

AU - Kurts, Christian

AU - Schultze, Joachim L.

AU - Kastenmüller, Wolfgang

AU - Knolle, Percy A.

PY - 2015/9/25

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AB - Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX 3 CR1 distinguishes memory CD8+ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3 CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8+ T cells with effector function. We find CD62L hi CX3 CR1+ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1+ memory CD8+ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3 CR1-based functional classification will help to resolve the principles of protective CD8+ T-cell memory.

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JO - Nature Communications

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Functional classification of memory CD8 + T cells by CX 3 CR1 expression

Abstract

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