TY - JOUR
T1 - From more to less than Haber's law
AU - Schramm, Karl Werner
AU - Ghergut, Iulia
AU - Behechti, Akbar
AU - Rozman, Karl K.
AU - Kettrup, Antonius
PY - 2002
Y1 - 2002
N2 - We show how reformulating a first-order response theory with respect to both toxicant concentration and exposure time, in terms of relative instead of absolute increments, leads to a generalized version of Haber's law and to a combined sigmoid model for concentration and time response, derived on analytical rather than empirical grounds. More general presuppositions of Haber's law (without assuming sigmoid response) are briefly discussed. The relative intensities of time response and concentration response are measured by a single dimensionless parameter, characterizing each quadruple {toxicant, route, species, adverse effect}. Cross-species and cross-toxicant variability of this parameter is discussed and illustrated by new findings on algae and Daphniae exposed to selected inorganic and organic pollutants.
AB - We show how reformulating a first-order response theory with respect to both toxicant concentration and exposure time, in terms of relative instead of absolute increments, leads to a generalized version of Haber's law and to a combined sigmoid model for concentration and time response, derived on analytical rather than empirical grounds. More general presuppositions of Haber's law (without assuming sigmoid response) are briefly discussed. The relative intensities of time response and concentration response are measured by a single dimensionless parameter, characterizing each quadruple {toxicant, route, species, adverse effect}. Cross-species and cross-toxicant variability of this parameter is discussed and illustrated by new findings on algae and Daphniae exposed to selected inorganic and organic pollutants.
KW - Daphnia magna
KW - Endpoint conversions
KW - Haber's law
KW - Pentachlorophenol
KW - Scenedesmus subspicatus
KW - Time-dose additivity
UR - http://www.scopus.com/inward/record.url?scp=0036290182&partnerID=8YFLogxK
U2 - 10.1016/S1382-6689(02)00009-1
DO - 10.1016/S1382-6689(02)00009-1
M3 - Article
AN - SCOPUS:0036290182
SN - 1382-6689
VL - 11
SP - 227
EP - 232
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
IS - 3-4
ER -