Fibroblasts – the cellular choreographers of wound healing

Samuel Knoedler; Sonja Broichhausen; Ruiji Guo; Ruoxuan Dai; Leonard Knoedler; Martin Kauke-Navarro; Fortunay Diatta; Bohdan Pomahac; Hans Guenther Machens; Dongsheng Jiang; Yuval Rinkevich

doi:10.3389/fimmu.2023.1233800

Fibroblasts – the cellular choreographers of wound healing

Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans Guenther Machens, Dongsheng Jiang, Yuval Rinkevich

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

15 Zitate (Scopus)

Abstract

Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.

Originalsprache	Englisch
Aufsatznummer	1233800
Fachzeitschrift	Frontiers in Immunology
Jahrgang	14
DOIs	https://doi.org/10.3389/fimmu.2023.1233800
Publikationsstatus	Veröffentlicht - 2023
Extern publiziert	Ja

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10.3389/fimmu.2023.1233800

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title = "Fibroblasts – the cellular choreographers of wound healing",

abstract = "Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.",

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author = "Samuel Knoedler and Sonja Broichhausen and Ruiji Guo and Ruoxuan Dai and Leonard Knoedler and Martin Kauke-Navarro and Fortunay Diatta and Bohdan Pomahac and Machens, {Hans Guenther} and Dongsheng Jiang and Yuval Rinkevich",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Knoedler, Broichhausen, Guo, Dai, Knoedler, Kauke-Navarro, Diatta, Pomahac, Machens, Jiang and Rinkevich.",

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doi = "10.3389/fimmu.2023.1233800",

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AU - Knoedler, Samuel

AU - Broichhausen, Sonja

AU - Guo, Ruiji

AU - Dai, Ruoxuan

AU - Knoedler, Leonard

AU - Kauke-Navarro, Martin

AU - Diatta, Fortunay

AU - Pomahac, Bohdan

AU - Machens, Hans Guenther

AU - Jiang, Dongsheng

AU - Rinkevich, Yuval

PY - 2023

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N2 - Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.

AB - Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.

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KW - fibroblast

KW - fibroblast diversity

KW - skin injury

KW - skin regeneration

KW - wound healing

KW - wound repair

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Fibroblasts – the cellular choreographers of wound healing

Abstract

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