TY - JOUR
T1 - Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide
AU - Anastassiadis, C.
AU - Rottmann, O.
AU - Hörmansdorfer, S.
AU - Pirchner, F.
PY - 1997
Y1 - 1997
N2 - Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.
AB - Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.
UR - http://www.scopus.com/inward/record.url?scp=0031527744&partnerID=8YFLogxK
U2 - 10.1111/j.1439-0388.1997.tb00508.x
DO - 10.1111/j.1439-0388.1997.tb00508.x
M3 - Article
AN - SCOPUS:0031527744
SN - 0931-2668
VL - 114
SP - 225
EP - 230
JO - Journal of Animal Breeding and Genetics
JF - Journal of Animal Breeding and Genetics
IS - 3
ER -
