TY - JOUR
T1 - Exploiting cross-amyloid interactions to inhibit protein aggregation but not function
T2 - Nanomolar affinity inhibition of insulin aggregation by an IAPP mimic
AU - Velkova, Aleksandra
AU - Tatarek-Nossol, Marianna
AU - Andreetto, Erika
AU - Kapurniotu, Aphrodite
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Potential aggregate preventer: The designed peptide IAPP-GI inhibits the non-native aggregation of insulin without affecting its function. As the peptide also blocks aggregation of key amyloid peptides that occur in Alzheimer's disease and type II diabetes, it is a promising drug candidate. (Chemical Equation Presented)
AB - Potential aggregate preventer: The designed peptide IAPP-GI inhibits the non-native aggregation of insulin without affecting its function. As the peptide also blocks aggregation of key amyloid peptides that occur in Alzheimer's disease and type II diabetes, it is a promising drug candidate. (Chemical Equation Presented)
KW - Diabetes
KW - Insulin
KW - Islet amyloid polypeptide
KW - Protein aggregation
KW - Protein design
UR - http://www.scopus.com/inward/record.url?scp=54749122331&partnerID=8YFLogxK
U2 - 10.1002/anie.200801499
DO - 10.1002/anie.200801499
M3 - Article
AN - SCOPUS:54749122331
SN - 1433-7851
VL - 47
SP - 7114
EP - 7118
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 37
ER -
