Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Nicole M. Myer; Kohei Shitara; Hyun C. Chung; Florian Lordick; Ronan J. Kelly; Zsolt Szabo; Z. Alexander Cao; Stephen Leong; David H. Ilson; Wilko Weichert

doi:10.1007/s00432-021-03902-1

Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Nicole M. Myer
, Kohei Shitara
, Hyun C. Chung
, Florian Lordick
, Ronan J. Kelly
, Zsolt Szabo
, Z. Alexander Cao
, Stephen Leong
, David H. Ilson
, Wilko Weichert

Lehrstuhl für Pathologie

DNAX Research Institute
National Cancer Center Hospital East
Yonsei University College of Medicine
University Hospital Leipzig
Baylor University Medical Center
Weill Cornell Medical College

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

9 Zitate (Scopus)

Abstract

Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

Originalsprache	Englisch
Seiten (von - bis)	2023-2043
Seitenumfang	21
Fachzeitschrift	Journal of Cancer Research and Clinical Oncology
Jahrgang	148
Ausgabenummer	8
DOIs	https://doi.org/10.1007/s00432-021-03902-1
Publikationsstatus	Veröffentlicht - Aug. 2022

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title = "Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer",

abstract = "Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.",

keywords = "Biomarkers, Gastric cancer, Microsatellite instability, Programmed death ligand 1, Tumor mutational burden",

author = "Myer, \{Nicole M.\} and Kohei Shitara and Chung, \{Hyun C.\} and Florian Lordick and Kelly, \{Ronan J.\} and Zsolt Szabo and Cao, \{Z. Alexander\} and Stephen Leong and Ilson, \{David H.\} and Wilko Weichert",

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doi = "10.1007/s00432-021-03902-1",

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AU - Myer, Nicole M.

AU - Shitara, Kohei

AU - Chung, Hyun C.

AU - Lordick, Florian

AU - Kelly, Ronan J.

AU - Szabo, Zsolt

AU - Cao, Z. Alexander

AU - Leong, Stephen

AU - Ilson, David H.

AU - Weichert, Wilko

PY - 2022/8

Y1 - 2022/8

N2 - Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

AB - Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

KW - Biomarkers

KW - Gastric cancer

KW - Microsatellite instability

KW - Programmed death ligand 1

KW - Tumor mutational burden

UR - https://www.scopus.com/pages/publications/85130193223

U2 - 10.1007/s00432-021-03902-1

DO - 10.1007/s00432-021-03902-1

M3 - Review article

C2 - 35551464

AN - SCOPUS:85130193223

SN - 0171-5216

VL - 148

SP - 2023

EP - 2043

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

IS - 8

ER -

Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Abstract

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