Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Nicole M. Myer; Kohei Shitara; Hyun C. Chung; Florian Lordick; Ronan J. Kelly; Zsolt Szabo; Z. Alexander Cao; Stephen Leong; David H. Ilson; Wilko Weichert

doi:10.1007/s00432-021-03902-1

Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Nicole M. Myer, Kohei Shitara, Hyun C. Chung, Florian Lordick, Ronan J. Kelly, Zsolt Szabo, Z. Alexander Cao, Stephen Leong, David H. Ilson, Wilko Weichert

Lehrstuhl für Pathologie

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

6 Zitate (Scopus)

Abstract

Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

Originalsprache	Englisch
Seiten (von - bis)	2023-2043
Seitenumfang	21
Fachzeitschrift	Journal of Cancer Research and Clinical Oncology
Jahrgang	148
Ausgabenummer	8
DOIs	https://doi.org/10.1007/s00432-021-03902-1
Publikationsstatus	Veröffentlicht - Aug. 2022

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abstract = "Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.",

keywords = "Biomarkers, Gastric cancer, Microsatellite instability, Programmed death ligand 1, Tumor mutational burden",

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AU - Myer, Nicole M.

AU - Shitara, Kohei

AU - Chung, Hyun C.

AU - Lordick, Florian

AU - Kelly, Ronan J.

AU - Szabo, Zsolt

AU - Cao, Z. Alexander

AU - Leong, Stephen

AU - Ilson, David H.

AU - Weichert, Wilko

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N2 - Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

AB - Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

KW - Biomarkers

KW - Gastric cancer

KW - Microsatellite instability

KW - Programmed death ligand 1

KW - Tumor mutational burden

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JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

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Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

Abstract

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