@article{d7d6c029fa244e86881fb9e527b719cc,
title = "Evidence for an ancient chromosomal duplication in Arabidopsis thaliana by sequencing and analyzing a 400-kb contig at the APETALA2 locus on chromosome 4",
abstract = "As part of the European Scientists Sequencing Arabidopsis program, a contiguous region (396 607 bp) located on chromosome 4 around the APETALA2 gene was sequenced. Analysis of the sequence and comparison to public databases predicts 103 genes in this area, which represents a gene density of one gene per 3.85 kb. Almost half of the genes show no significant homology to known database entries. In addition, the first 45 kb of the contig, which covers 11 genes, is similar to a region on chromosome 2, as far as coding sequences are concerned. This observation indicates that ancient duplications of large pieces of DNA have occurred in Arabidopsis. Copyright (C) 1999 Federation of European Biochemical Societies.",
keywords = "APETALA2, Arabidopsis thaliana, Genome, Sequencing",
author = "Nancy Terryn and Leo Heijnen and {De Keyser}, Annick and {Van Asseldonck}, Martien and {De Clercq}, Rebecca and Henk Verbakel and Jan Gielen and Marc Zabeau and Raimundo Villarroel and Taco Jesse and Pia Neyt and Ren{\'e} Hogers and {Van Den Daele}, Hilde and Wilson Ardiles and Christine Schueller and Klaus Mayer and Patrice D{\'e}hais and Stephane Rombauts and {Van Montagu}, Marc and Pierre Rouz{\'e} and Pieter Vos",
note = "Funding Information: The authors wish to acknowledge the ABRC Stock Center in Ohio for the distribution of ESTs, M. Bevan for coordinating the ESSA program, H.W. Mewes, S. Klostermann, and N. Chalwatzis from MIPS for computer data analysis, Peter Breyne and Koen Goethals for critical reading of the manuscript, M. De Cock for help preparing it, and Rebecca Verbanck for the figures. This work was supported by the EU (Biotech ERBB102-CT93-0075 and ERBB104-CT96-0338) and by the Flemish government (VLAB-COT). ",
year = "1999",
month = feb,
day = "26",
doi = "10.1016/S0014-5793(99)00097-6",
language = "English",
volume = "445",
pages = "237--245",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "2-3",
}