@article{2b05f83132484e5c97e6dbe473d72951,
title = "Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)",
abstract = "This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.",
keywords = "Acrylamide, Genotoxic carcinogen, Non-linear dose response, Risk assessment, Thresholded MoA, Tolerable daily intake",
author = "Sabine Guth and Matthias Baum and Cartus, {Alexander T.} and Patrick Diel and Engel, {Karl Heinz} and Barbara Engeli and Bernd Epe and Tilman Grune and Dirk Haller and Volker Heinz and Michael Hellwig and Hengstler, {Jan G.} and Thomas Henle and Humpf, {Hans Ulrich} and Henry J{\"a}ger and Joost, {Hans Georg} and Kulling, {Sabine E.} and Lachenmeier, {Dirk W.} and Alfonso Lampen and Marcel Leist and Angela Mally and Doris Marko and Ute N{\"o}thlings and Elke R{\"o}hrdanz and Angelika Roth and Joachim Spranger and Richard Stadler and Pablo Steinberg and Stefan Vieths and Wim W{\"a}tjen and Gerhard Eisenbrand",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = mar,
doi = "10.1016/j.fct.2023.113632",
language = "English",
volume = "173",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Ltd.",
}