Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe; Stephan A. Sieber; Nina G. Bandur; Ulrich Koert; Mohamed A. Marahiel

doi:10.1002/cbic.200400042

Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe
, Stephan A. Sieber
, Nina G. Bandur
, Ulrich Koert
, Mohamed A. Marahiel

Philipps-Universität Marburg

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

24 Zitate (Scopus)

Abstract

A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

Originalsprache	Englisch
Seiten (von - bis)	1000-1003
Seitenumfang	4
Fachzeitschrift	ChemBioChem
Jahrgang	5
Ausgabenummer	7
DOIs	https://doi.org/10.1002/cbic.200400042
Publikationsstatus	Veröffentlicht - 5 Juli 2004
Extern publiziert	Ja

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10.1002/cbic.200400042

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abstract = "A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.",

keywords = "Alkene dipeptide isostere, Antibiotics, Peptide cyclases, Peptidomimetics, Postsynthetic modification",

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AU - Koert, Ulrich

AU - Marahiel, Mohamed A.

PY - 2004/7/5

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AB - A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

KW - Alkene dipeptide isostere

KW - Antibiotics

KW - Peptide cyclases

KW - Peptidomimetics

KW - Postsynthetic modification

UR - https://www.scopus.com/pages/publications/4544240965

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Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Abstract

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