Abstract
The first examples of enantioselective intermolecular [2+2] photocycloadditions of isoquinolone with alkenes are reported. Photoreactions were carried out at low temperature in the presence of a chiral hydrogen-bonding template, which effectively shields one face of the substrate through formation of a hydrogen-bonded supramolecular complex. Functionalized cyclobutane products were obtained in excellent yields (86-98%) and with outstanding regio-, diastereo-, and enantioselectivity (88-99% ee).
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 14948-14951 |
| Seitenumfang | 4 |
| Fachzeitschrift | Journal of the American Chemical Society |
| Jahrgang | 135 |
| Ausgabenummer | 40 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 9 Okt. 2013 |