(Enantio)selective Hydrogen Autotransfer: Ruthenium-Catalyzed Synthesis of Oxazolidin-2-ones from Urea and Diols

Miguel Peña-López, Helfried Neumann, Matthias Beller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

64 Zitate (Scopus)

Abstract

A novel strategy for the synthesis of oxazolidin-2-ones from vicinal diols and urea is described. In this heterocycle synthesis, two different C−O and C−N bonds are sequentially formed in a domino process consisting of nucleophilic substitution and alcohol amination. The use of readily available starting materials and the good atom economy render this process environmentally benign. While this transformation is already highly chemo- and regioselective, we also developed the first asymmetric version of this method using (R)-(+)-MeO-BIPHEP as the chiral ligand.

OriginalspracheEnglisch
Seiten (von - bis)7826-7830
Seitenumfang5
FachzeitschriftAngewandte Chemie International Edition in English
Jahrgang55
Ausgabenummer27
DOIs
PublikationsstatusVeröffentlicht - 27 Juni 2016
Extern publiziertJa

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