TY - JOUR
T1 - Effect of Perioperative Administration of a Drug Regimen on the Primary Function of Human Renal Allografts
AU - Brauer, R. B.
AU - Marx, T.
AU - Ulm, K.
AU - Stangl, M. J.
PY - 2010/6
Y1 - 2010/6
N2 - Delayed graft function (DGF) has one of the greatest effects on short- and long-term outcomes of cadaveric renal allografts. Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. Thus, the effectiveness of PGE1 in combination with high-dose furosemide and dopamine in diminishing DGF was not demonstrated in this trial.
AB - Delayed graft function (DGF) has one of the greatest effects on short- and long-term outcomes of cadaveric renal allografts. Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. Thus, the effectiveness of PGE1 in combination with high-dose furosemide and dopamine in diminishing DGF was not demonstrated in this trial.
UR - http://www.scopus.com/inward/record.url?scp=77953677800&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2010.01.057
DO - 10.1016/j.transproceed.2010.01.057
M3 - Article
C2 - 20620467
AN - SCOPUS:77953677800
SN - 0041-1345
VL - 42
SP - 1523
EP - 1525
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 5
ER -