TY - JOUR
T1 - Early clinical and structural results after autologous chondrocyte transplantation at the glenohumeral joint
AU - Buchmann, Stefan
AU - Salzmann, Gian M.
AU - Glanzmann, Michael C.
AU - Wörtler, Klaus
AU - Vogt, Stephan
AU - Imhoff, Andreas B.
PY - 2012/9
Y1 - 2012/9
N2 - Background: The purpose of the study was to report early functional and radiographic results of a small series of patients who underwent autologous chondrocyte transplantation-collagen membrane seeding (ACT-Cs) for focal chondral defects of the shoulder. Methods: The outcome of 4 consecutive male patients (mean age, 29.3 ± 6.2 years; range, 21-36 years) who underwent ACT-Cs for treatment of large symptomatic glenohumeral cartilage defects was retrospectively evaluated with clinical and radiographic measures at a mean of 41.3 ± 24.9 months (range, 11-71 months) after surgery. The evaluation included a visual analog scale for pain, the Constant score, the American Shoulder and Elbow Surgeons shoulder index, the Rowe score, and a satisfaction scale. Magnetic resonance imaging evaluation was performed according to the Magnetic Resonance Observation of Cartilage Repair Tissue scoring system. Results: There were 3 humeral full-thickness cartilage defects (each 6.0 cm2) and 1 glenoid full-thickness cartilage defect (2.0 cm2). The mean postoperative visual analog scale score (0.3 of 10), the mean unweighted Constant score (83.3 ± 9.9), and the mean American Shoulder and Elbow Surgeons index (95.3 ± 8.1) were representative of satisfactory shoulder function. The Magnetic Resonance Observation of Cartilage Repair Tissue score was indicative of satisfactory defect coverage with signs of fibrocartilaginous repair tissue. Conclusions: Autologous chondrocyte transplantation at the glenohumeral joint is a remote option for young adults with symptomatic, isolated, large-diameter cartilage lesions. Potential complications as a result of the open approach and 2-step procedure have to be considered carefully. Long-term data, larger patient populations, and randomized studies are required to determine the potential for chondrocyte transplantation techniques to be standard procedure for treatment of symptomatic, large-diameter, full-thickness cartilage defects in the glenohumeral joint.
AB - Background: The purpose of the study was to report early functional and radiographic results of a small series of patients who underwent autologous chondrocyte transplantation-collagen membrane seeding (ACT-Cs) for focal chondral defects of the shoulder. Methods: The outcome of 4 consecutive male patients (mean age, 29.3 ± 6.2 years; range, 21-36 years) who underwent ACT-Cs for treatment of large symptomatic glenohumeral cartilage defects was retrospectively evaluated with clinical and radiographic measures at a mean of 41.3 ± 24.9 months (range, 11-71 months) after surgery. The evaluation included a visual analog scale for pain, the Constant score, the American Shoulder and Elbow Surgeons shoulder index, the Rowe score, and a satisfaction scale. Magnetic resonance imaging evaluation was performed according to the Magnetic Resonance Observation of Cartilage Repair Tissue scoring system. Results: There were 3 humeral full-thickness cartilage defects (each 6.0 cm2) and 1 glenoid full-thickness cartilage defect (2.0 cm2). The mean postoperative visual analog scale score (0.3 of 10), the mean unweighted Constant score (83.3 ± 9.9), and the mean American Shoulder and Elbow Surgeons index (95.3 ± 8.1) were representative of satisfactory shoulder function. The Magnetic Resonance Observation of Cartilage Repair Tissue score was indicative of satisfactory defect coverage with signs of fibrocartilaginous repair tissue. Conclusions: Autologous chondrocyte transplantation at the glenohumeral joint is a remote option for young adults with symptomatic, isolated, large-diameter cartilage lesions. Potential complications as a result of the open approach and 2-step procedure have to be considered carefully. Long-term data, larger patient populations, and randomized studies are required to determine the potential for chondrocyte transplantation techniques to be standard procedure for treatment of symptomatic, large-diameter, full-thickness cartilage defects in the glenohumeral joint.
KW - Articular cartilage
KW - Autologous chondrocyte transplantation
KW - Cartilage defect
KW - Collagen matrix
KW - Glenohumeral joint
UR - http://www.scopus.com/inward/record.url?scp=84865076895&partnerID=8YFLogxK
U2 - 10.1016/j.jse.2011.07.030
DO - 10.1016/j.jse.2011.07.030
M3 - Article
C2 - 22047789
AN - SCOPUS:84865076895
SN - 1058-2746
VL - 21
SP - 1213
EP - 1221
JO - Journal of Shoulder and Elbow Surgery
JF - Journal of Shoulder and Elbow Surgery
IS - 9
ER -