Early clinical and structural results after autologous chondrocyte transplantation at the glenohumeral joint

Stefan Buchmann, Gian M. Salzmann, Michael C. Glanzmann, Klaus Wörtler, Stephan Vogt, Andreas B. Imhoff

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

36 Zitate (Scopus)

Abstract

Background: The purpose of the study was to report early functional and radiographic results of a small series of patients who underwent autologous chondrocyte transplantation-collagen membrane seeding (ACT-Cs) for focal chondral defects of the shoulder. Methods: The outcome of 4 consecutive male patients (mean age, 29.3 ± 6.2 years; range, 21-36 years) who underwent ACT-Cs for treatment of large symptomatic glenohumeral cartilage defects was retrospectively evaluated with clinical and radiographic measures at a mean of 41.3 ± 24.9 months (range, 11-71 months) after surgery. The evaluation included a visual analog scale for pain, the Constant score, the American Shoulder and Elbow Surgeons shoulder index, the Rowe score, and a satisfaction scale. Magnetic resonance imaging evaluation was performed according to the Magnetic Resonance Observation of Cartilage Repair Tissue scoring system. Results: There were 3 humeral full-thickness cartilage defects (each 6.0 cm2) and 1 glenoid full-thickness cartilage defect (2.0 cm2). The mean postoperative visual analog scale score (0.3 of 10), the mean unweighted Constant score (83.3 ± 9.9), and the mean American Shoulder and Elbow Surgeons index (95.3 ± 8.1) were representative of satisfactory shoulder function. The Magnetic Resonance Observation of Cartilage Repair Tissue score was indicative of satisfactory defect coverage with signs of fibrocartilaginous repair tissue. Conclusions: Autologous chondrocyte transplantation at the glenohumeral joint is a remote option for young adults with symptomatic, isolated, large-diameter cartilage lesions. Potential complications as a result of the open approach and 2-step procedure have to be considered carefully. Long-term data, larger patient populations, and randomized studies are required to determine the potential for chondrocyte transplantation techniques to be standard procedure for treatment of symptomatic, large-diameter, full-thickness cartilage defects in the glenohumeral joint.

OriginalspracheEnglisch
Seiten (von - bis)1213-1221
Seitenumfang9
FachzeitschriftJournal of Shoulder and Elbow Surgery
Jahrgang21
Ausgabenummer9
DOIs
PublikationsstatusVeröffentlicht - Sept. 2012
Extern publiziertJa

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