Dynamics of beta‐adrenoceptor blockade with cetamolol.

J. Coelho, K. Schnelle, L. Joubert, D. Ventura, J. Mullane

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

5 Zitate (Scopus)

Abstract

Cetamolol is a new beta‐adrenoceptor blocking agent shown in animals to have moderate beta 1‐adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1‐adrenoceptor blockade was measured as the reduction of exercise‐induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. beta 1‐adrenoceptor blockade was significantly linearly related to log serum cetamolol level, was maximal at 2 h, and was still clinically significant at 24 h. A crossover study of single 0, 10, and 25 mg doses confirmed these findings. 1985 The British Pharmacological Society

OriginalspracheEnglisch
Seiten (von - bis)411-416
Seitenumfang6
FachzeitschriftBritish Journal of Clinical Pharmacology
Jahrgang19
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - Apr. 1985

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