Dynamics in the solid-state: Perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes

Rasmus Linser, Riddhiman Sarkar, Alexey Krushelnitzky, Andi Mainz, Bernd Reif

Publikation: Beitrag in FachzeitschriftÜbersichtsartikelBegutachtung

33 Zitate (Scopus)

Abstract

Aggregates formed by amyloidogenic peptides and proteins and reconstituted membrane protein preparations differ significantly in terms of the spectral quality that they display in solid-state NMR experiments. Structural heterogeneity and dynamics can both in principle account for that observation. This perspectives article aims to point out challenges and limitations, but also potential opportunities in the investigation of these systems.

OriginalspracheEnglisch
Seiten (von - bis)1-14
Seitenumfang14
FachzeitschriftJournal of Biomolecular NMR
Jahrgang59
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - Mai 2014
Extern publiziertJa

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