TY - JOUR
T1 - Dynamic retinal vessel response to flicker in obesity
T2 - A methodological approach
AU - Kotliar, Konstantin E.
AU - Lanzl, Ines M.
AU - Schmidt-Trucksäss, Arno
AU - Sitnikova, Diana
AU - Ali, Mohammad
AU - Blume, Katharina
AU - Halle, Martin
AU - Hanssen, Henner
PY - 2011/1
Y1 - 2011/1
N2 - Obesity and related metabolic disorders affect vascular endothelial function. The use of the Dynamic Vessel Analyzer (DVA) represents a modern methodological approach to analyze vascular function in the retinal microcirculation. Whether the dynamic reaction to flicker stimulation in retinal vessels is altered in obese subjects is investigated. Retinal vessel reactions to flicker stimulation were examined by DVA in 46 obese individuals (49.6 ± 10.0. years) and 46 age- and gender-matched healthy controls. The clinical examination included anthropometry, blood pressure measurements and blood sampling. Mean maximal arteriolar dilation in response to flicker was reduced in the obese group (3.2 ± 1.8%) compared to controls (4.1 ± 2.0%, p < 0.05) and the time to maximal arteriolar dilation was prolonged (18.0 ± 9.4. s vs. 14.6 ± 3.8. s, p = 0.03). In addition, mean maximal venular dilation was reduced in obese subjects (3.9 ± 1.7% vs. 4.7 ± 1.8%, p < 0.05). Among the microvascular parameters, the most significant correlation with waist circumference was found for the "area under the reaction curve 50-80. s after stimulation" in arterioles (r = -0.40; p < 0.001). Functional retinal arteriolar reactivity to flicker stimulation differs between obese and healthy lean subjects. Time course analysis of retinal vessel response and its quantitative parameters can comprehensively characterize alterations of retinal vessel reactivity in metabolic disease.
AB - Obesity and related metabolic disorders affect vascular endothelial function. The use of the Dynamic Vessel Analyzer (DVA) represents a modern methodological approach to analyze vascular function in the retinal microcirculation. Whether the dynamic reaction to flicker stimulation in retinal vessels is altered in obese subjects is investigated. Retinal vessel reactions to flicker stimulation were examined by DVA in 46 obese individuals (49.6 ± 10.0. years) and 46 age- and gender-matched healthy controls. The clinical examination included anthropometry, blood pressure measurements and blood sampling. Mean maximal arteriolar dilation in response to flicker was reduced in the obese group (3.2 ± 1.8%) compared to controls (4.1 ± 2.0%, p < 0.05) and the time to maximal arteriolar dilation was prolonged (18.0 ± 9.4. s vs. 14.6 ± 3.8. s, p = 0.03). In addition, mean maximal venular dilation was reduced in obese subjects (3.9 ± 1.7% vs. 4.7 ± 1.8%, p < 0.05). Among the microvascular parameters, the most significant correlation with waist circumference was found for the "area under the reaction curve 50-80. s after stimulation" in arterioles (r = -0.40; p < 0.001). Functional retinal arteriolar reactivity to flicker stimulation differs between obese and healthy lean subjects. Time course analysis of retinal vessel response and its quantitative parameters can comprehensively characterize alterations of retinal vessel reactivity in metabolic disease.
KW - Flicker stimulation
KW - Microcirculation
KW - Obesity
KW - Retinal vessel reactivity
UR - http://www.scopus.com/inward/record.url?scp=78650766515&partnerID=8YFLogxK
U2 - 10.1016/j.mvr.2010.11.007
DO - 10.1016/j.mvr.2010.11.007
M3 - Article
C2 - 21094174
AN - SCOPUS:78650766515
SN - 0026-2862
VL - 81
SP - 123
EP - 128
JO - Microvascular Research
JF - Microvascular Research
IS - 1
ER -
