Dynamic mechanistic modeling of the multienzymatic one-pot reduction of dehydrocholic acid to 12-keto ursodeoxycholic acid with competing substrates and cofactors

Keyphrases

• Keto 100%
• Ursodeoxycholic Acid 100%
• Mechanistic Modeling 100%
• Dehydrocholic Acid 100%
• Competing Substrates 100%
• Bile Acids 75%
• Batch Process 50%
• Rate Equations 50%
• Hydroxysteroid Dehydrogenase 50%
• Prediction Accuracy 25%
• Oxidation State 25%
• Primary Sclerosing Cholangitis 25%
• Validation Experiment 25%
• One-pot Reaction 25%
• Regeneration 25%
• Two-step Reduction 25%
• Mass Balance 25%
• Mechanistic Model 25%
• Co-substrate 25%
• Glucose Dehydrogenase 25%
• Optimum Reaction Conditions 25%
• Kinetic Mechanism 25%
• Full Process 25%
• Substrate Inhibition 25%
• Equation Balance 25%
• Progress Curve Analysis 25%
• Cholesterol Gallstones 25%
• Ordered Bi-bi Mechanism 25%
• Primary Biliary Cirrhosis 25%
• Chemoenzymatic Synthesis 25%
• Synthesis Routes 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Dehydrocholic Acid 100%
• Ursodeoxycholic Acid 100%
• Bile Acid 75%
• Cholesterol Stone 25%
• Glucose Dehydrogenase 25%
• Primary Sclerosing Cholangitis 25%
• Hydroxysteroid Dehydrogenase 25%
• Disease 25%
• 3(or 17)beta Hydroxysteroid Dehydrogenase 25%
• Primary Biliary Cirrhosis 25%