@article{f3dbd9b3f6104d139f7dd7d09bf25323,
title = "Dynamic adoption of anergy by antigen-exhausted CD4+ T cells",
abstract = "In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.",
keywords = "CD4 T cells, T cell receptor, anergy, exhaustion, gene expression, microarray, tolerance, transcriptomics, tuning",
author = "Anne Trefzer and Pallavi Kadam and Wang, {Shu Hung} and Stefanie Pennavaria and Benedikt Lober and Batuhan Ak{\c c}abozan and Jan Kranich and Thomas Brocker and Naoko Nakano and Martin Irmler and Johannes Beckers and Tobias Straub and Reinhard Obst",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = feb,
day = "9",
doi = "10.1016/j.celrep.2021.108748",
language = "English",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier B.V.",
number = "6",
}