Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing

Keyphrases

• Transcriptional Repression 100%
• Poly-GA 100%
• Cellular Models 100%
• C9orf72 mutation 100%
• Pentatricopeptide Repeat Protein 100%
• Dipeptide Repeats 100%
• Model mutation 100%
• Poly-GR 80%
• Nucleolar 80%
• Poly-PR 80%
• Spinal Cord 40%
• C9orf72 40%
• Neurodegeneration 40%
• Intranuclear 40%
• UNC119 40%
• Cerebellum 20%
• Coding Region 20%
• Frontotemporal Dementia 20%
• Neuropathology 20%
• Expression Pattern 20%
• Brainstem 20%
• Amyotrophic Lateral Sclerosis 20%
• Non-associated 20%
• Interacting Proteins 20%
• Colocalization 20%
• Gene Transcription 20%
• Overexpression 20%
• Nucleolus 20%
• Start Codon 20%
• Hippocampus 20%
• H3K9me3 20%
• Primary Neurons 20%
• Regional Distribution 20%
• Subcellular Distribution 20%
• Heterochromatin 20%
• Neocortex 20%
• Postmortem Brain 20%
• Ependymal 20%
• Granular Cell Layer 20%
• CGG Repeat 20%
• Neuronal Inclusions 20%
• Subependymal 20%
• Glial Cytoplasmic Inclusion 20%
• Nucleolar Stress 20%

Neuroscience

• Dipeptide 100%
• Frontotemporal Dementia 44%
• Neurodegeneration 22%
• Cerebellum 11%
• Coding Region 11%
• Hippocampus 11%
• Thalamus 11%
• Heterochromatin 11%
• Brainstem 11%
• Start Codon 11%
• Genetic Transcription 11%
• Amyotrophic Lateral Sclerosis 11%