Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity

Keyphrases

• Alzheimer's Disease 10%
• Alzheimer's Type 7%
• Amyloid Cytotoxicity 100%
• Amyloid Formation 100%
• Amyloid-β Peptide 7%
• Amyloidogenesis 3%
• C-terminal Region 3%
• Cell Degeneration 3%
• Cell Toxicity 3%
• Cytotoxicity 10%
• Fibrillogenesis 7%
• Heterocomplex 3%
• High Affinity 3%
• Hot Region 3%
• Hotspot Regions 3%
• Human Islet Amyloid Polypeptide (hIAPP) 100%
• Inhibitory Activity 10%
• Inhibitory Effect 7%
• Interaction Interface 7%
• Molecular Determinants 3%
• Molecular Link 3%
• N-terminal Region 3%
• N-terminus 3%
• Nonfibrillar 3%
• Novel Inhibitors 3%
• Polypeptide 3%
• Polypeptide 1 10%
• Self-assembly 3%
• Self-association 10%
• Type 2 Diabetes Mellitus (T2DM) 10%

Neuroscience

• Alzheimer's Disease 10%
• Amino Terminal Sequence 10%
• Amylin 100%
• Amyloid Protein 100%
• C-Terminus 7%
• Cell Degeneration 3%
• Cytotoxicity 100%
• Polypeptide 3%

Biochemistry, Genetics and Molecular Biology

• Amylin 100%
• Amyloid Protein 100%
• C-Terminus 7%
• Cell Degeneration 3%
• Cytotoxicity 100%
• Fibrillogenesis 7%
• N-Terminus 10%