Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Sara Della Torre, Valeria Benedusi, Giovanna Pepe, Clara Meda, Nicoletta Rizzi, Nina Henriette Uhlenhaut, Adriana Maggi

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

24 Zitate (Scopus)

Abstract

In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ERα) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ERα KO mice demonstrates that the hepatic ERα, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ERα might be a valuable target for dietary treatments for the post-menopause.

OriginalspracheEnglisch
Aufsatznummer6883
FachzeitschriftNature Communications
Jahrgang12
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - Dez. 2021

Fingerprint

Untersuchen Sie die Forschungsthemen von „Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren