Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Sebastian Brings; Thomas Fleming; Marc Freichel; Martina U. Muckenthaler; Stephan Herzig; Peter P. Nawroth

doi:10.3390/ijms18050984

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Sebastian Brings, Thomas Fleming, Marc Freichel, Martina U. Muckenthaler, Stephan Herzig, Peter P. Nawroth

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

160 Zitate (Scopus)

Abstract

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

Originalsprache	Englisch
Aufsatznummer	984
Fachzeitschrift	International Journal of Molecular Sciences
Jahrgang	18
Ausgabenummer	5
DOIs	https://doi.org/10.3390/ijms18050984
Publikationsstatus	Veröffentlicht - 5 Mai 2017
Extern publiziert	Ja

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AU - Brings, Sebastian

AU - Fleming, Thomas

AU - Freichel, Marc

AU - Muckenthaler, Martina U.

AU - Herzig, Stephan

AU - Nawroth, Peter P.

PY - 2017/5/5

Y1 - 2017/5/5

N2 - Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

AB - Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

KW - 3-deoxyglucosone

KW - Advanced glycation end-products

KW - Aldose reductase

KW - Diabetes

KW - Glyoxal

KW - Glyoxalase

KW - Methylglyoxal

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Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Abstract

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