TY - GEN
T1 - Detection of detrimental effects on health in Point-of-Care scenarios using a multiparametric biosensor
AU - Schmidhuber, M.
AU - Wiest, J.
AU - Grundl, D.
AU - Brückl, M.
AU - Büchels, N.
AU - Wolf, B.
PY - 2008
Y1 - 2008
N2 - A whole-cell biosensor with its miniaturized electronic is described. Various interfaces including a built-in GSM modem allow a wide application field in Point-of-Care scenarios. Improvements designing the fluidic module and also reducing the costs for the biochip should lead to a disposable and easy-to-use system. Design concepts are described. In this handheld system a multiparametric biochip based on cost-effective ceramic substrate is used. The cells cultivated upon this biochip act as a signal converter for monitoring environmental changes in their surrounding micromilieu. The measurement of their vitality parameters pH, pO2 and impedance allows an estimation of the impact on the metabolic activity due to the added agent or compound. Analysing the signal response profiles using various cell lines enables an extended field of application. Example measurements from chemosensitivity experiments are shown. The way towards Point-of-Care applications in water quality monitoring and food analysis is described.
AB - A whole-cell biosensor with its miniaturized electronic is described. Various interfaces including a built-in GSM modem allow a wide application field in Point-of-Care scenarios. Improvements designing the fluidic module and also reducing the costs for the biochip should lead to a disposable and easy-to-use system. Design concepts are described. In this handheld system a multiparametric biochip based on cost-effective ceramic substrate is used. The cells cultivated upon this biochip act as a signal converter for monitoring environmental changes in their surrounding micromilieu. The measurement of their vitality parameters pH, pO2 and impedance allows an estimation of the impact on the metabolic activity due to the added agent or compound. Analysing the signal response profiles using various cell lines enables an extended field of application. Example measurements from chemosensitivity experiments are shown. The way towards Point-of-Care applications in water quality monitoring and food analysis is described.
KW - Cell-signalconverter
KW - Labs-on-chip
KW - Multiparametric sensorarray
KW - Point-of-care diagnosis
UR - http://www.scopus.com/inward/record.url?scp=62949150611&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:62949150611
SN - 9780889867215
T3 - Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008
SP - 298
EP - 301
BT - Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008
T2 - 6th IASTED International Conference on Biomedical Engineering, BioMED 2008
Y2 - 13 February 2008 through 15 February 2008
ER -