TY - JOUR
T1 - Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
AU - Xie, Kan
AU - Fuchs, Helmut
AU - Scifo, Enzo
AU - Liu, Dan
AU - Aziz, Ahmad
AU - Aguilar-Pimentel, Juan Antonio
AU - Amarie, Oana Veronica
AU - Becker, Lore
AU - da Silva-Buttkus, Patricia
AU - Calzada-Wack, Julia
AU - Cho, Yi Li
AU - Deng, Yushuang
AU - Edwards, A. Cole
AU - Garrett, Lillian
AU - Georgopoulou, Christina
AU - Gerlini, Raffaele
AU - Hölter, Sabine M.
AU - Klein-Rodewald, Tanja
AU - Kramer, Michael
AU - Leuchtenberger, Stefanie
AU - Lountzi, Dimitra
AU - Mayer-Kuckuk, Phillip
AU - Nover, Lena L.
AU - Oestereicher, Manuela A.
AU - Overkott, Clemens
AU - Pearson, Brandon L.
AU - Rathkolb, Birgit
AU - Rozman, Jan
AU - Russ, Jenny
AU - Schaaf, Kristina
AU - Spielmann, Nadine
AU - Sanz-Moreno, Adrián
AU - Stoeger, Claudia
AU - Treise, Irina
AU - Bano, Daniele
AU - Busch, Dirk H.
AU - Graw, Jochen
AU - Klingenspor, Martin
AU - Klopstock, Thomas
AU - Mock, Beverly A.
AU - Salomoni, Paolo
AU - Schmidt-Weber, Carsten
AU - Weiergräber, Marco
AU - Wolf, Eckhard
AU - Wurst, Wolfgang
AU - Gailus-Durner, Valérie
AU - Breteler, Monique M.B.
AU - Hrabě de Angelis, Martin
AU - Ehninger, Dan
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.
AB - Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.
UR - http://www.scopus.com/inward/record.url?scp=85141729347&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-34515-y
DO - 10.1038/s41467-022-34515-y
M3 - Article
C2 - 36369285
AN - SCOPUS:85141729347
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 6830
ER -