Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Luigi Messori; Angela Casini; Chiara Gabbiani; Elena Michelucci; Leticia Cubo; Carla Ríos-Luci; José M. Padrón; Carmen Navarro-Ranninger; Adoracion G. Quiroga

doi:10.1021/ml100081e

Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Luigi Messori, Angela Casini, Chiara Gabbiani, Elena Michelucci, Leticia Cubo, Carla Ríos-Luci, José M. Padrón, Carmen Navarro-Ranninger, Adoracion G. Quiroga

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

32 Zitate (Scopus)

Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Originalsprache	Englisch
Seiten (von - bis)	381-385
Seitenumfang	5
Fachzeitschrift	ACS Medicinal Chemistry Letters
Jahrgang	1
Ausgabenummer	8
DOIs	https://doi.org/10.1021/ml100081e
Publikationsstatus	Veröffentlicht - 11 Nov. 2010
Extern publiziert	Ja

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10.1021/ml100081e

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abstract = "Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.",

keywords = "DNA and protein interaction, Iodidoplatinum complex, cytotoxicity",

author = "Luigi Messori and Angela Casini and Chiara Gabbiani and Elena Michelucci and Leticia Cubo and Carla R{\'i}os-Luci and Padr{\'o}n, {Jos{\'e} M.} and Carmen Navarro-Ranninger and Quiroga, {Adoracion G.}",

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doi = "10.1021/ml100081e",

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T1 - Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

AU - Messori, Luigi

AU - Casini, Angela

AU - Gabbiani, Chiara

AU - Michelucci, Elena

AU - Cubo, Leticia

AU - Ríos-Luci, Carla

AU - Padrón, José M.

AU - Navarro-Ranninger, Carmen

AU - Quiroga, Adoracion G.

PY - 2010/11/11

Y1 - 2010/11/11

N2 - Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

AB - Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

KW - DNA and protein interaction

KW - Iodidoplatinum complex

KW - cytotoxicity

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U2 - 10.1021/ml100081e

DO - 10.1021/ml100081e

M3 - Article

AN - SCOPUS:78649234226

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SP - 381

EP - 385

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 8

ER -

Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Abstract

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