Cytochrome P 450 content and the ability of liver microsomes from patients undergoing abdominal surgery to alter the mutagenicity of a primary and a secondary carcinogen

P. Czygan, H. Greim, A. J. Garro, F. Hutterer, J. Rudick, F. Schaffner, H. Popper

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

22 Zitate (Scopus)

Abstract

The capacity of microsomes isolated from patients undergoing abdominal surgery to alter the mutagenicity of a primary and a secondary carcinogen was investigated and related to the cytochrome P 450 content of the liver. Such microsomes activated the mutagenic effect on bacteria of the secondary carcinogen dimethylnitrosamine and inactivated that of the primary carcinogen N methyl N nitro N nitrosoguanidine. The differential ability of microsomes to alter mutagenicity varied in parallel with cytochrome P 450 content. This suggests great variability in the capacity of patients examined to metabolize carcinogens by their microsomes.

OriginalspracheEnglisch
Seiten (von - bis)1761-1764
Seitenumfang4
FachzeitschriftUnknown Journal
Jahrgang51
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 1973
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „Cytochrome P 450 content and the ability of liver microsomes from patients undergoing abdominal surgery to alter the mutagenicity of a primary and a secondary carcinogen“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren