Abstract
The capacity of microsomes isolated from patients undergoing abdominal surgery to alter the mutagenicity of a primary and a secondary carcinogen was investigated and related to the cytochrome P 450 content of the liver. Such microsomes activated the mutagenic effect on bacteria of the secondary carcinogen dimethylnitrosamine and inactivated that of the primary carcinogen N methyl N nitro N nitrosoguanidine. The differential ability of microsomes to alter mutagenicity varied in parallel with cytochrome P 450 content. This suggests great variability in the capacity of patients examined to metabolize carcinogens by their microsomes.
Originalsprache | Englisch |
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Seiten (von - bis) | 1761-1764 |
Seitenumfang | 4 |
Fachzeitschrift | Unknown Journal |
Jahrgang | 51 |
Ausgabenummer | 6 |
DOIs | |
Publikationsstatus | Veröffentlicht - 1973 |
Extern publiziert | Ja |