Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers

Keyphrases

• Gene Expression 100%
• Distal Enhancer 100%
• Sequence-to-sequence Model 100%
• Human Genome 25%
• Causal Effect 25%
• Regulatory Elements 25%
• Promoter Region 25%
• Training Model 25%
• Sequence Variation 25%
• Class Imbalance 25%
• Receptive Field 25%
• In Silico Study 25%
• Long Distance 25%
• Long-term Information 25%
• Practical Guidance 25%
• Human Genes 25%
• Transcription Regulation 25%
• Promoter Variants 25%
• Transcription Control 25%
• Large-scale Observational Study 25%
• Human Promoter 25%
• Gene Regulatory Programs 25%
• State-of-the-art Models 25%
• Causal Signals 25%
• Large Sequences 25%
• Causal Determinant 25%
• Gene Expression Prediction 25%

Biochemistry, Genetics and Molecular Biology

• Promoter Region 100%
• Gene Expression 100%
• Enhancer Region 100%
• Transcription 25%
• Regulatory Element 25%
• Observational Study 25%
• Locus Control Region 25%
• In Silico Study 25%
• Transcription Regulation 25%
• Human Genome 25%
• Receptive Field 25%
• Pribnow Box 25%